BSCB Newsletter, Winter 2005
Hooke medal winner
year's Hooke medal lecture will be given by David Owen from the new
Cambridge Institute for Medical Research.
has been an independent researcher since 2000 and has an outstanding
track record in applying structural methods to proteins involved in
membrane trafficking. His lab uses a combination of structural (protein
X-ray crystallography, in collaboration with Phil Evans MRC Laboratory
of Molecular Biology), biochemical, biophysical and cell biological
studies on individual domains, whole proteins and protein complexes
from a variety of vesicle coats.
current work focuses on the AP2, AP1, GGA1 clathrin adaptors (with Scottie
Robinson CIMR) and the COPI complex, which is distantly related to APs
and involved in trafficking from the Golgi to the endoplasmic reticulum
(with Rainer Duden University of London).
collaboration with Mathew Seaman (CIMR) they are studying the structure
and function of components of the retromer complex that is involved
in non-clathrin mediated traffic from endosomes and with Stefan Honing
(University of Gottingen) they are also studying how the recruitment
of vesicle coats is regulated.